C4d – RMab

For In Vitro Diagnostic Use

Complement component 4, or C4, plays a central role in the complement system. C4d is the final proteolytic remnant of deposited C4b on endothelium and remains covalently attached to endothelium for little more than a week. It is easily detectable by Immunohistochemistry. Anti-C4d combined with anti-C3d can be utilized as a tool for diagnosis of AR (Acute Rejection) and warrant prompt and aggressive anti-rejection treatment. C4d can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.

Antibody Type: Rabbit Monoclonal
Isotype: IgG
Localization: Cytoplasmic, Membranous
Clone: EP273
Reactivity: Paraffin, Frozen
Control: Tonsil, Lymph Node, Spleen, Kidney, Kidney Transplant Rejection

C4d is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.