CD138 – RMab

For In Vitro Diagnostic Use

CD138/Syndecan-1 is a transmembrane heparin-sulphate proteoglycan consisting of one core protein and five glycosaminoglycans. CD138 is suspected to play a role in cell adhesion. It is expressed on the surface of pre B-cells and plasma cells but is absent from mature B-cells.
Anti-CD138/syndecan-1 is a useful marker for labeling normal and neoplastic plasma cells and Plasmacytoid Lymphomas. It is a selective marker for B-cell Lymphoblastic Leukemia and Lymphoplasmocytoid Leukemia. It is lost from the apoptotic myeloma cells, and thus, is a useful marker for viable Myeloma cells. Various forms of Hodgkin’s Disease have also shown positive staining with this antibody.

Antibody Type Rabbit Monoclonal
Clone EP201
Isotype IgG
Reactivity Paraffin, Frozen
Localization Membranous
Control Tonsil, Liver, Kidney, Breast, Lymph Node, Cervix, Plasmacytoma, Adrenal, Skin, Colon

CD138 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.