CD25 – RMab

For In Vitro Diagnostic Use

CD25 is the alpha chain of the IL-2 receptor. It is a type I transmembrane protein present on activated T cells, activated B cells, some thymocytes, myeloid precursors, and oligodendrocytes that associates with CD122 to form a heterodimer that can act as a high-affinity receptor for IL-2. Studies have shown that a large proportion of resting memory T cells constitutively express CD25. CD25 is expressed in most B-cell neoplasms, some acute nonlymphocytic leukemias, neuroblastomas, and tumor infiltrating lymphocytes. Its soluble form, called sIL-2R may be elevated in these diseases and is occasionally used to track disease progression. CD25 is also utilized in cases of mastocytosis

Antibody Type Rabbit Monoclonal
Clone RBT-CD25
Isotype IgG
Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous
Control Tonsil, Small Bowel, Spleen, Mastocytosis,Hodgkin’s Lymphoma

CD25 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.