CD31 – MMab

For In Vitro Diagnostic Use

CD31 is also called PECAM-1 for platelet endothelial cell-adhesion molecule. It plays a key role in removing aged neutrophils from the body. CD-31 is normally found on stem cells, endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T/NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts and neutrophils. CD-31 is also expressed in certain tumors, including Epithelioid Hemangioendothelioma, Epithelioid Sarcoma-like Hemangioendothelioma, other vascular tumors, Histiocytic malignancies, and Plasmacytomas. It is rarely found in some sarcomas and carcinomas. CD-31 and macrophages play a key role in tissue regeneration. CD31 is widely used to identify the vascular origin of neoplasms, as it is a highly specific and sensitive marker for vascular endothelial cells.

Antibody Type Mouse Monoclonal
Clone 1A10
Isotype IgG1/K
Reactivity Paraffin, Frozen
Localization Cytoplasmic, Membranous
Control Tonsil, Placenta, Appendix, Spleen, Kidney

CD31 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.