CD35 – MMab

For In Vitro Diagnostic Use

CD35 (erythrocyte complement receptor 1 or CR1, also known as C3b/C4b receptor and immune adherence receptor) serves as the main system for processing and clearance of complement- opsonized immune complexes. The number of CR1 molecules decreases with aging of erythrocytes in normal individuals and is also decreased in pathological conditions such as Systemic Lupus Erythematosus (SLE), HIV infection, some Hemolytic Anemias and other conditions featuring immune complexes. Anti-CD35 is considered a mature B-cell marker, which labels follicular dendritic reticulum cells and tumors derived from such cells such as Follicular Dendritic Cell Tumor/Sarcoma. CD35 antigen is found in erythrocytes, B-cells, and a subset of T-cells, monocytes, as well as in eosinophils and neutrophils.

Antibody Type Mouse Monoclonal
Clone RLB25
Isotype IgG2b
Reactivity Paraffin, Frozen
Localization Membranous
Control Tonsil, Lymph Node

CD35 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative..