CD41/Integrin alpha IIb – RMab

For In Vitro Diagnostic Use

ITGA2B encodes CD41, or integrin alpha IIb. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain IIb undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface medicated signaling.

CD41 expression has been found on platelets, megakaryocyes, and immature hematopoietic progenitors.

Antibody Type Rabbit Monoclonal
Clone EP178
Isotype IgG
Reactivity Paraffin, Frozen
Localization Membranous, Cytoplasmic
Control Bone Marrow, Spleen

CD41 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.