CD7 – RMab

For In Vitro Diagnostic Use

CD7 is a 40 kDa transmembrane, single-chain glycoprotein, which is a member of the immunoglobulin gene superfamily. It is expressed in the majority of immature and mature T-lymphocytes and T-cell Leukemia. CD7 is also found in natural killer cells, a small subpopulation of normal B-cells and in malignant B-cells. It plays an essential role in T-cell interactions and also in T-cell/B-cell interactions during early lymphoid development.
CD7 is a consistently-expressed T-cell antigen in Lymphoblastic Lymphomas and Leukemias; therefore, it is a useful marker in the identification of such neoplastic proliferations. CD7 is expressed in the majority of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, some myeloid cells, T-cell Acute Lymphoblastic Leukemia/Lymphoma, Acute Myelogenous Leukemia and Chronic Myelogenous Leukemia. Interestingly, CD7 is conspicuously absent in adult T-cell Leukemia/Lymphoma and is not expressed in Sezary cells.

Antibody Type Rabbit Monoclonal
Clone EP132
Isotype IgG
Reactivity Paraffin, Frozen
Localization Membranous
Control Tonsil, Lymph Node, Colon, Liver, Spleen, Bone Marrow, Lymphoblastic, Lymphoma

CD7 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.