Claudin-1 – Rabbit Polyclonal

For In Vitro Diagnostic Use

Claudin 1 is an integral membrane protein and a component of tight junction strands. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet.

Claudin-1 stains membranes of cells and is found in nearly all carcinomas, with stains much stronger in carcinoma cells than in normal tissue cells.

Antibody Type Rabbit Polyclonal
Clone Polyclonal
Isotype IgG
Reactivity Paraffin, Frozen
Localization Membranous, Cytoplasmic
Control Skin, Small intestine. Perineurioma, Neurofibroma, colon Carcinoma

Claudin 1 is a Rabbit Polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.