Claudin-5 – RMab

For In Vitro Diagnostic Use

Claudin-5 is a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction (TJ) strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-5 is an endothelial cell-specific component of TJ strands. Mutations in Claudin-5 have been found in patients with velocardiofacial syndrome.
Claudin-5 labels endothelial cells and has been used as a marker for endothelial lesions. Claudin-5 is also found in bronchial and lung epithelial cells. In tumors, Claudin-5 expression has been found in lung adenocarcinoma and squamous carcinoma. In serous ovarian adenocarcinoma, increased Claudin-5 expression is associated with aggressive behavior.

Antibody Type Rabbit Monoclonal
Clone EP224
Isotype IgG
Reactivity Paraffin, Frozen
Localization Membranous
Control Liver, Vascular Tissue, Placenta, Colon, Kidney, Fallopian Tube

Claudin-5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.