Cytokeratin 20 – RMab

For In Vitro Diagnostic Use

Cytokeratin 20 (CK 20) is a 46 kDa intermediate filament protein whose expression is restricted primarily to gastric and intestinal epithelium, urothelium, and Merkel cells. Cytokeratin 20 is a Type I cytokeratin. It is a major cellular protein of mature enterocytes and goblet cells found in the gastric and intestinal mucosa.

CK 20 is expressed in Adenocarcinomas of the colon, stomach, pancreas and biliary system. It is also expressed in Mucinous Ovarian Tumors, Transitional-cell Carcinomas of the urinary tract, and Merkel-cell Carcinomas. Cytokeratin 20 is useful in the differentiation of specific types of simple epithelial cells of the urinary tract and normal and malignantly-transformed epithelia. This antibody is essentially non-reactive in Squamous Cell Carcinomas and Adenocarcinomas of the Breast, Lung, and Endometrium, Non-mucinous Tumors of the Ovary, and Small-cell Carcinomas. This antibody is often used in conjunction with CK 7 and other antibodies to distinguish Colon Carcinomas (CK20+) from Ovarian, Pulmonary, and Breast Carcinomas.

Antibody Type Rabbit Monoclonal
Clone EP23
Isotype IgG2a/K
Reactivity Paraffin, Frozen
Localization Cytoplasmic
Control Colon Carcinoma, Colon Mucosa, Bladder

CK20 is a Rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.