FOXP3 – Rabbit Polyclonal

For In Vitro Diagnostic Use

FOXP3, also known as scurfin, is a protein involved in immune system responses. A member of the forkhead box protein family, FOXP3 appears to function as a transcription factor in the development and function of regulatory T cells. In regulatory T cell model systems, the FOXP3 transcription factor occupies the promoters of many important for regulatory T-cell function, and may repress transcription of key genes following stimulation of T cell receptors.

Alterations in numbers of regulatory T-cells – in particular those that express FOXP3 – are found in a number of disease states. Patients with tumors have a local relative excess of FOXP3 positive T cells which inhibits the body’s ability to suppress the formation of cancerous cells.

Antibody Type: Rabbit Monoclonal
Clone: EP340
Isotype: IgG
Reactivity: Paraffin, Frozen
Localization: Nuclear
Control: Tonsil, Lymph Node, Thym

FOXP3 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.