Galectin-3–MMab

For In Vitro Diagnostic Use

Galectin-3 is a 31 kDa beta-galactosidase binding lectin. It has been associated with binding to the basement membrane glycoprotein laminin. Galectin-3 is normally distributed in epithelia of many organs and various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins. Anti-Galectin-3 has been demonstrated to be valuable in differentiating between benign and malignant thyroid neoplasms in both histologic sections and Fine Needle Aspiration Biopsy material. Anti-Galectin-3 antibody has also been useful in identifying Anaplastic Large Cell Lymphoma.

Antibody Type: Mouse Monoclonal
Clone: 9C4
Isotype; IgG1
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic
Control: Kidney, Testis, Salivary Gland, Breast, Tonsil, Colon, Papillary, Follicular Carcinoma of Thyroid

Galectin-3 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.