Granzyme B – RMab

For In Vitro Diagnostic Use

Granzymes are exogenous serine proteases that are released by cytoplasmic granules within cytotoxic T-cells and natural killer cells. Their purpose is to induce apoptosis within virus-infected cells, thus destroying them.
Anti-Granzyme B antibodies have been useful in diagnosing Natural Killer/T-cell Lymphoma, as well as Anaplastic Large Cell Lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin’s Disease.

Antibody Type: Rabbit Monoclonal
Clone: EP230
Isotype: IgG
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic (Granular)
Control: Liver, Testis, Cervix, Tonsil, Lymph Node, Spleen

Granzyme B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.