HIF-1a – Rmab

Analyte Specific Reagent: analytical and performance characteristics are not established

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a protein that in humans is encoded by the HIF1A gene. Two alternative transcripts encoding different isoforms have been identified, the alpha and beta subunits. HIF-1 plays an essential role in cellular and systemic responses to hypoxia.
HIF-1 is a critical mediator of the hypoxic response that upregulates expression of proteins that promote angiogenesis, anaerobic metabolism, and many other survival pathways. HIF-1alpha is expressed in many types of tumors. The expression of HIF-1alpha is correlated with tumor angiogenesis, cancer progression and clinical outcome in various solid tumors including breast cancer, type 1 endometrial carcinoma, sarcoma, head and neck tumor and brain tumor. Importantly, hypoxia has been clinically demonstrated to predict an adverse treatment outcome in theradiotherapeutic management of cancer of the head and neck, uterine cervix and soft tissue sarcoma

Antibody Type: Rabbitt Monoclonal
Clone: EP118
Isotype: IgG
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic, Nuclear
Control: Tonsil, Cervix, Liver, Testis, Kidney, Breast, Thymus, Spleen, Colon, Cervical Cancer

HIF-1 alpha is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.