Ksp-Cadherin – MMAb

For In Vitro Diagnostic Use

Ksp-Cadherin (Kidney-specific Cadherin) is a novel, kidney-specific member of the Cadherin family of cell-adhesion molecules. Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels. Different Cadherins, including E-Cadherin, Cadherin-6, and N-Cadherin, have been investigated in Renal Cell Cancers, demonstrating possible correlations of tumor differentiation and the presence of lymph node metastasis with loss of Cadherins. Ksp-Cadherin has been used to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma. Studies have found a membranous pattern of staining in 96% of 30 Chromophobe Carcinomas, and in only 6% of 31 Oncocytomas, leading to conclude that this is a useful antibody in differentiating these two lesions. On the other hand, another study found Ksp-Cadherin positivity in 100% of 13 chromophobe RCCs, and 95% of 20 Oncocytomas.

Antibody Type: Mouse Monoclonal
Clone: 4H6/F9
Isotype: IgG1
Reactivity: Paraffin, Frozen
Localization:Membranous, Cytoplasmic
Control: Thyroid, Kidney, Chromophobe Renal Cell Carcinoma

Ksp-Cadherin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.