PAX-2 – RMab

For In Vitro Diagnostic Use.

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features.Anti-PAX-2 can be used to distinguish Ovarian Serous Papillary Carcinoma (PAX-2 positive) from Primary Breast Carcinoma (PAX-2 negative). It can also be used to distinguish Clear Cell Renal Carcinoma (positive) from Hepatocellular Carcinoma
(negative).

Antibody Type: Rabbit Monoclonal
Clone: EP235
Isotype: IgG
Reactivity: Paraffin, Frozen
Localization: Nuclear
Control: Kidney, Fallopian Tube, Clear Cell Renal Carcinoma, Ovarian Serous Papillary Carcinoma

PAX-2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.