TintoFast Cytokeratin 5 & 6 (D5/16D4), MMab

For Mohs In Vitro Diagnostic Use

Cytokeratin 6 (56 kD) is also a high-molecular weight, basic type cytokeratin expressed by proliferating squamous epithelium often paired with Cytokeratin 16.

TintoFast Cytokeratin 5 & 6 are positively seen in nearly 100% of Malignant Mesotheliomas and is rarely seen in Lung Adenocarcinomas. TintoFast Cytokeratin 5 & 6 can positively be seen in undifferentiated Large-cell Carcinoma as well as Squamous Carcinoma. Fewer than 10% of Carcinomas of the breast, colon, and prostate stain positively for this marker. CK 5 and 6 have also been used successfully as a myoepithelial cell marker in the prostate to determine malignancy.

Antibody Type: Mouse Monoclonal
Clone: D5/16B4
Isotype: IgG1
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic
Control: SCC/BCC

Anti-CK 5 & 6 is a cocktail of mouse monoclonal antibodies derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.