TintoFast Cytokeratin AE1/AE3 (AE1/AE3), MMab

For Mohs In Vitro Diagnostic Use

There are two types of cytokeratins: the low-weight, acidic Type I cytokeratins and the high-weight, basic or neutral Type II cytokeratins. Cytokeratins are usually found in pairs comprising a Type I cytokeratin and a Type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue-specific.

TintoFast Cytokeratin AE1/AE3 is well suited to distinguish Epithelial Carcinoma from Non-epithelial malignancies and is used to aid Epithelial Tumor classification. This antibody has been used to characterize the source of various neoplasms and to study the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues. TintoFast Cytokeratin AE1/AE3 has shown high sensitivity and specificity in recognizing epithelial cells of neoplastic origin.

Antibody Type: Mouse Monoclonal
Clone: AE1/AE3
Isotype: IgG1
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic
Control: Skin, SCC, BCC

Anti – Cytokeratin AE1/AE3 is a cocktail of mouse monoclonal antibodies derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.