TintoFast EpCAM BerEP4 (Ber-EP4), MMab

For Mohs In Vitro Diagnostic Use

These glycoproteins are located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells, with the exception of most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. However, focal positivity may be seen in the basal layer of squamous cell epithelium of endoderm (e.g., palatine tonsils) and mesoderm (e.g., uterine cervix).

TintoFast EpCAM BerEP4 expression has been reported to be a possible marker of early malignancy, with expression being increased in tumor cells, and de novo expression being seen in dysplastic squamous epithelium. Epithelial specific antigen has been known to play an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma. EpCAM can be used to distinguish among Basal Cell, Basosquamous Carcinomas and Squamous Cell Carcinomas of the skin.

Antibody Type: Mouse Monoclonal
Clone: Ber-EP4
Isotype: IgG1/K
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic
Control: BCC, EMPD

Anti – EpCAM BerEP4 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.