TLE1 – MMab

For In Vitro Diagnostic Use

The Notch signaling pathway controls cellular interactions important for the specifi cation of a variety of fates
in both invertebrates and vertebrates. Key players in the Notch pathway are the TLE genes. TLEs associate
with chromatin in live cells and specifi cally with Histone H3, but not with other core histones. Expression of
the TLE genes, TLE1, TLE2, TLE3 and TLE4, correlate with immature epithelial cells that are progressing toward
a terminally diff erentiated state, suggesting a role during epithelial diff erentation.
Anti-TLE1 can be used to diff erentiate synovial sarcoma from other sarcomas, including histologically similar
tumors such as malignant peripheral nerve sheath tumor.

Antibody Type: Mouse Monoclonal
Clone: 1F5
Isotype: IgG1/K
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic, Nuclear
Control: Synovial Sarcoma

TLE1 is a Mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.