Villin – MMab

For In Vitro Diagnostic Use

Villin is an actin-binding protein that contains gelsolin domains capped by a ”headpiece” consisting of a fast and independently-folding three-helix bundle stabilized by hydrophobic interactions. The headpiece domain is a commonly-studied protein in molecular dynamics due to its fast-folding kinetics and short primary sequence. It is a regulator of the actin cytoskeleton and is expressed mainly in the brush border in animals.
Anti-Villin labels the brush border area in the gastrointestinal mucosal epithelium. This antibody has been useful in differentiating Gastrointestinal Adenocarcinoma, Neuroendocrine Carcinomas and Ovarian Adenocarcinomas from Adenocarcinomas of other organs. Also labeled by this antibody are Merkel cells of the skin.

Antibody Type: Mouse Monoclonal
Clone: CWWB1
Isotype: IgG1
Reactivity: Paraffin, Frozen
Localization: Cytoplasmic Membranous
Control: Kidney, Colon, Small Bowel Mucosa, Colonic Mucosa

Anti-Villin is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.